• Poly(azomethine) Based Micelles for Delivery of Caffeic Acid Phenethyl Ester

  • Nermin Saliha Topuzogullari, Fatma Sayan Poyraz, Murat Topuzogullari*, and Banu Mansuroglu† 

  • Yildiz Technical University, Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, 34220, Türkiye
    *Yildiz Technical University, Faculty of Chemical and Metallurgical Engineering, Department of Bioengineering, 34220, Türkiye

  • Cafferic Acid Phenethyl Ester 전달을 위한 Poly(azomethine) 기반 마이셀 연구

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

Poly(azomethine) based micelles have been developed for the delivery of caffeic acid phenethyl ester (CAPE). These micelles, synthesized from a polyazomethine-PEG block copolymer, demonstrate significant potential in drug release systems due to its pH-sensitive biodegradable nature. Characterization through SEM revealed spherical micelles with an average diameter of 135.5 nm. The micelles' drug release behavior was studied at physiological (pH 7.2) and lysosomal (pH 5.0) pH levels. The findings indicated pH sensitive release of CAPE from the micelle of which only 2.14% of CAPE was released at pH 7.2 while 38.8% of CAPE was released at pH 5.0 after 24 h. In vitro cell viability assays using human-derived fibroblast cells showed that CAPE-loaded micelles exhibited minimal toxicity after 48 hours compared to CAPE and free micelle. These results suggest the potential of polyazomethine-based micelles as efficient carriers for targeted drug delivery for therapeutic purposes.


Keywords: drug delivery, micelle, pH-sensitive, polyazomethine, polyimine.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2025; 49(3): 277-284

    Published online May 25, 2025

  • 10.7317/pk.2025.49.3.277
  • Received on Jul 9, 2024
  • Revised on Nov 25, 2024
  • Accepted on Dec 24, 2024

Correspondence to

  • Banu Mansuroglu

  • Yildiz Technical University, Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, 34220, Türkiye

  • E-mail: bmansur@yildiz.edu.tr