• Design, Optimization, and Evaluation of a Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Parsley n-Hexane Fraction Utilizing Coconut Oil as the Oil Phase
  • Edwin J. Bunggulawa, Yeong-kwan Lee*, **, and Yong-kyu Lee*, **,†

  • Department of Green Bioengineering, Korea National University of Transportation, Chungju 27470, Korea
    *Department of Chemical & Biological Engineering, Korea National University of Transportation, Chungju 27470, Korea
    **4D Convergence Technology Institute, Korea National University of Transportation, Jeungpyeong 27909, Korea

  • 코코넛오일을 유상상으로 활용한 파슬리 n-헥산 분획의 경구 전달용 자기나노유화약물전달시스템(SNEDDS)의 설계, 최적화 및 평가
  • 에드윈제이카붕굴라와 · 이영관*, ** · 이용규*, **,†

  • 국립한국교통대학교 녹색바이오공학과, *국립한국교통대학교 화공생물공학과, **국립한국교통대학교 4D 바이오용합소재 산업화센터

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Mosihuzzaman, M. Herbal Medicine in Healthcare-an Overview. Nat. Prod. Commun. 2012, 7, DOI:10.1177/1934578X1200700628.
  •  
  • 2. Firenzuoli, F.; Gori, L. Herbal Medicine Today: Clinical and Research Issues. Evidence‐Based Complement. Altern. Medicine 2007, 4, 37-40.
  •  
  • 3. Khan, M. S. A.; Ahmad, I. Herbal Medicine: Current Trends and Future Prospects. In New look to Phytomedicine, Elsevier: London, 2019; pp 3-13.
  •  
  • 4. Punoševac, M.; Radović, J.; Leković, A.; Kundaković-Vasović, T. A Review of Botanical Characteristics, Chemical Composition, Pharmacological Activity and Use of Parsley. Archiv. Pharm. 2021, 71, 177-196.
  •  
  • 5. Suryani, S.; Zubaydah, W. O. S.; Sahumena, M. H.; Adawia, S.; Wahyuni, R.; Adjeng, A. N. T.; Nisa, M.; Kasmawati, H.; Ihsan, S.; Ruslin, R. Preparation and Characterization of Self-nanoemulsifying Drug Delivery System (SNEDDS) from Moringa Oleifera L. and Cassia alata L. Leaves Extracts, AIP Conf. Proc. 2019, 2197, 070011.
  •  
  • 6. Saraf, S. Applications of Novel Drug Delivery System for Herbal Formulations. Fitoterapia 2010, 81, 680-689.
  •  
  • 7. Pouton, C. W. Formulation of Self-emulsifying Drug Delivery Systems. Adv. Drug Delivery Rev. 1997, 25, 47-58.
  •  
  • 8. Narang, A. S.; Delmarre, D.; Gao, D. Stable Drug Encapsulation in Micelles and Microemulsions. Int. J. Pharm. 2007, 345, 9-25.
  •  
  • 9. Suhery, W. N.; Djohari, M.; Nur, N. R. Pengaruh Jenis Minyak Terhadap Karakterisasi Sifat Fisik dan Disolusi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Asam Fenofibrat. JOPS 2023, 7, 1-9.
  •  
  • 10. Hosny, K. M.; Alhakamy, N. A.; Sindi, A. M.; Khallaf, R. A., Coconut Oil Nanoemulsion Loaded with a Statin Hypolipidemic Drug for Management of Burns: Formulation and in vivo Evaluation. Pharmaceutics 2020, 12, 1061.
  •  
  • 11. Narayanankutty, A.; Illam, S. P.; Raghavamenon, A. C. Health Impacts of Different Edible Oils Prepared from Coconut (Cocos nucifera): A Comprehensive Review. Trends in Food Sci. Technol. 2018, 80, 1-7.
  •  
  • 12. Esclapez, M.; García-Pérez, J. V.; Mulet, A.; Cárcel, J. Ultrasound-assisted Extraction of Natural Products. Food Eng. Rev. 2011, 3, 108-120.
  •  
  • 13. Shafazila, T.; Lee, P. M.; Hung, L. K. Radical Scavenging Activities of Extract and Solvent-solvent Partition Fractions from Dendrobium Sonia “Red Bom” Flower, 2010 International Conference on Science and Social Research (CSSR 2010), IEEE, 2010, pp 762-765.
  •  
  • 14. Hosny, K. M.; Rizg, W. Y.; Khallaf, R. A. Preparation and Optimization of in situ Gel Loaded with Rosuvastatin-ellagic Acid Nanotransfersomes to Enhance the Anti-proliferative Activity. Pharmaceutics 2020, 12, 263.
  •  
  • 15. Nasr, A.; Gardouh, A.; Ghonaim, H.; Abdelghany, E.; Ghorab, M. Effect of Oils, Surfactants and Cosurfactants on Phase Behavior and Physicochemical Properties of Self-nanoemulsifying Drug Delivery System (SNEDDS) for Irbesartan and Olmesartan. Int J. Appl. Pharm. 2016, 8, 13-24.
  •  
  • 16. Kanwal, T.; Saifullah, S.; ur Rehman, J.; Kawish, M.; Razzak, A.; Maharjan, R.; Imran, M.; Ali, I.; Roome, T.; Simjee, S. U. Design of Absorption Enhancer Containing Self-nanoemulsifying Drug Delivery System (SNEDDS) for Curcumin Improved Anti-cancer Activity and Oral Bioavailability. J. Mol. Liq. 2021, 324, 114774.
  •  
  • 17. Balakumar, K.; Raghavan, C. V.; Abdu, S. Self Nanoemulsifying Drug Delivery System (SNEDDS) of Rosuvastatin Calcium: Design, Formulation, Bioavailability and Pharmacokinetic Evaluation. Colloids Surf., B 2013, 112, 337-343.
  •  
  • 18. Elnaggar, Y. S.; El-Massik, M. A.; Abdallah, O. Y. Self-nanoemulsifying Drug Delivery Systems of Tamoxifen Citrate: Design and Optimization. Int. J. Pharm. 2009, 380, 133-141.
  •  
  • 19. Wahyuningsih, I.; Putranti, W. Optimasi Perbandingan Tween 80 Dan Polietilenglikol 400 Pada Formula Self Nanoemulsifying Drug Delivery System (SNEDDS) Minyak Biji Jinten Hitam. Pharm. J. Indones. 2015, 12, 223-241.
  •  
  • 20. Shukla, J. B.; Patel, S. J. Formulation and Evaluation of Self Micro Emulsifying System of Candesartan Cilexetil. Int. J. Pharm. Pharm. Sci. 2010, 2, 143-146.
  •  
  • 21. Gupta, S.; Chavhan, S.; Sawant, K. K. Self-nanoemulsifying Drug Delivery System for Adefovir Dipivoxil: Design, Characterization, in vitro and ex vivo Evaluation. Colloids Surf. A 2011, 392, 145-155.
  •  
  • 22. Sarheed, O.; Dibi, M.; Ramesh, K. V. Studies on the Effect of Oil and Surfactant on the Formation of Alginate-based O/W Lidocaine Nanocarriers Using Nanoemulsion Template. Pharmaceutics 2020, 12, 1223.
  •  
  • 23. Piriyaprasarth, S.; Sriamornsak, P.; Chansiri, G.; Promboot, W.; Imerb, U.; Sumpoung, D. Effect of Coconut Oil and Surfactants on Stability of Nanoemulsions. Adv. Mater. Res. 2012, 506, 429-432.
  •  
  • 24. Miksusanti, E. F. A.; Bihurinin, A. H. B. Optimization of Tween 80 and PEG-400 Concentration in Indonesian Virgin Coconut Oil Nanoemulsion as Antibacterial Against Staphylococcus Aureus. Sains Malaysiana 2023, 52, 1259-1272.
  •  
  • 25. Han, Y.; Gao, Z.; Chen, L.; Kang, L.; Huang, W.; Jin, M.; Wang, Q.; Bae, Y. H. Multifunctional Oral Delivery Systems for Enhanced Bioavailability of Therapeutic Peptides/proteins. Acta Pharmaceutica Sinica B 2019, 9, 902-922.
  •  
  • 26. Buya, A. B.; Beloqui, A.; Memvanga, P. B.; Préat, V. Self-nano-emulsifying Drug-delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery. Pharmaceutics 2020, 12, 1194.
  •  
  • 27. Kazi, M.; Al-Swairi, M.; Ahmad, A.; Raish, M.; Alanazi, F. K.; Badran, M. M.; Khan, A. A.; Alanazi, A. M.; Hussain, M. D. Evaluation of Self-nanoemulsifying Drug Delivery Systems (SNEDDS) for Poorly Water-soluble Talinolol: Preparation, in vitro and in vivo Assessment. Front. Pharmacol. 2019, 10, 459.
  •  
  • 28. Mohite, P.; Sule, S.; Pawar, A.; Alharbi, H. M.; Maitra, S.; Subramaniyan, V.; Kumarasamy, V.; Uti, D. E.; Ogbu, C. O.; Oodo, S. I. Development and Characterization of a Self-nano Emulsifying Drug Delivery System (SNEDDS) for Ornidazole to Improve Solubility and Oral Bioavailability of BCS Class II Drugs. Sci. Rep. 2024, 14, 27724.
  •  
  • 29. Morakul, B. Self-nanoemulsifying Drug Delivery Systems (SNEDDS): an Advancement Technology for Oral Drug Delivery. Pharm. Sci. Asia 2020, 47, 205-220.
  •  
  • 30. Baloch, J.; Sohail, M. F.; Sarwar, H. S.; Kiani, M. H.; Khan, G. M.; Jahan, S.; Rafay, M.; Chaudhry, M. T.; Yasinzai, M.; Shahnaz, G. Self-nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: in vitro and in vivo Evaluation. Medicina 2019, 55, 210.
  •  
  • 31. Ganea, M.; Vicaș, L. G.; Gligor, O.; Sarac, I.; Onisan, E.; Nagy, C.; Moisa, C.; Ghitea, T. C. Exploring the Therapeutic Efficacy of Parsley (Petroselinum crispum Mill.) as a Functional Food: Implications in Immunological Tolerability, Reduction of Muscle Cramps, and Treatment of Dermatitis. Molecules 2024, 29, 608.
  •  
  • 32. Es-Safi, I.; Mechchate, H.; Amaghnouje, A.; Kamaly, O. M. A.; Jawhari, F. Z.; Imtara, H.; Grafov, A.; Bousta, D. The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety: An in vivo Subacute Study. Molecules 2021, 26, 2009.
  •  
  • 33. Harmon, T. M.; Huang, J. Nano-Emulsion Formulations for Injection & Oral Administration. Drug Development & Delivery 2014, 14, 34-38.
  •  
  • 34. Jusril, N. A.; Abu Bakar, S. I.; Khalil, K. A.; Md Saad, W. M.; Wen, N. K.; Adenan, M. I. Development and Optimization of Nanoemulsion from Ethanolic Extract of Centella asiatica (NanoSECA) Using D‐Optimal Mixture Design to Improve Blood‐Brain Barrier Permeability. Evidence‐Based Complementary and Alternative Medicine 2022, 2022, 3483511.
  •  
  • 35. Zhang, C.; Li, B. Fabrication of Nanoemulsion Delivery System with High Bioaccessibility of Carotenoids from Lycium Barbarum by Spontaneous Emulsification. Food Sci. Nutr. 2022, 10, 2582-2589.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2025; 49(3): 375-385

    Published online May 25, 2025

  • 10.7317/pk.2025.49.3.375
  • Received on Jan 14, 2025
  • Revised on Jan 24, 2025
  • Accepted on Jan 29, 2025

Correspondence to

  • Yong-kyu Lee
  • *Department of Chemical & Biological Engineering, Korea National University of Transportation, Chungju 27470, Korea
    **4D Convergence Technology Institute, Korea National University of Transportation, Jeungpyeong 27909, Korea

  • E-mail: leeyk@ut.ac.kr