• Rheological and Textural Properties of Hydrogel Formulations Containing Nanostructured Lipid Carriers (NLCs) with Different Types of Polymeric Thickeners

  • Ju-Yeong Shin and Byung Suk Jin†

  • Division of Chemistry and Cosmetics, Dongduk Women’s University, Seoul 02748, Korea

  • 고분자 점증제 종류에 따른 나노구조 지질담체(NLC) 함유 하이드로젤 제형의 유변학적 및 텍스처 특성

  • 신주영 · 진병석†

  • 동덕여자대학교 화학·화장품학부

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Garud, A.; Singh, D.; Garud, N. Solid Lipid Nanoparticles (SLN): Method, Characterization and Applications. Int. Curr. Pharm. J. 2012, 11, 384-393.
  •  
  • 2. Müller, R. H.; Radtke, M.; Wissing, S. A. Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) in Cosmetic and Dermatological Preparations. Adv. Drug Deliv. Rev. 2002, 54, S131-S155.
  •  
  • 3. Garcês, A.; Amaral, M. H.; Lobo, J. S.; Silva, A. C. Formulations Based on Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for Cutaneous Use: A Review. Eur. J. Pharm. Sci. 2018, 112, 159-167.
  •  
  • 4. Pardeike, J.; Hommoss, A.; Müller, R. H. Lipid Nanoparticles (SLN, NLC) in Cosmetic and Pharmaceutical Dermal Products. Int. J. Pharm. 2009, 366, 170-184.
  •  
  • 5. Sharma, A.; Baldi, A. Nanostructured Lipid Carriers: A Review. J. Dev. Drugs 2018, 7, 1-15.
  •  
  • 6. Poonia, N.; Kharb, R.; Lather, V.; Pandita, D. Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle. Future Sci. OA 2016, 2, FSO135.
  •  
  • 7. Salvi, V. R.; Pawar, P. Nanostructured Lipid Carriers (NLC) System: A Novel Drug Targeting Carrier. J. Drug Deliv. Sci. Technol. 2019, 51, 255-267.
  •  
  • 8. Soleimanian, Y.; Goli, S. A. H.; Varshosaz, J.; Di Cesare Mannelli, L.; Ghelardini, C.; Cirri, M.; Maestrelli, F. β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity. Pharmaceutics 2020, 12, 386.
  •  
  • 9. Pardeike, J.; Schwabe, K.; Müller, R. H. Influence of Nanostructured Lipid Carriers (NLC) on the Physical Properties of the Cutanova Nanorepair Q10 Cream and the In Vivo Skin Hydration Effect. Int. J. Pharm.2010, 396, 166-173.
  •  
  • 10. Syed Azhar, S. N. A.; Ashari, S. E.; Zainuddin, N.; Hassan, M. Nanostructured Lipid Carriers–Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective. Molecules 2022, 27, 289.
  •  
  • 11. Müller, R. H.; Petersen, R. D.; Hommoss, A.; Pardeike, J. Nanostructured Lipid Carriers (NLC) in Cosmetic Dermal Products. Adv. Drug Deliv. Rev. 2007, 59, 522-530.
  •  
  • 12. de Araújo, M. M.; Schneid, A. C.; Oliveira, M. S.; Mussi, S. V.; de Freitas, M. N.; Carvalho, F. C.; Bernes, E. A., Jr.; Faro, R.; Azevedo, H. NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection. Pharmaceutics 2024, 16, 427.
  •  
  • 13. do Prado, A. H.; Araújo, V. H. S.; Eloy, J. O.; Fonseca-Santos, B.; Pereira-da-Silva, M. A.; Peccinini, R. G.; Chorilli, M. Synthesis and Characterization of Nanostructured Lipid Nanocarriers for Enhanced Sun Protection Factor of Octyl p-Methoxycinnamate. AAPS PharmSciTech 2020, 21, 125.
  •  
  • 14. Parga, A. D.; Ray, B. Advances in Nanocarrier Systems for Dermatologic Transdermal Drug Delivery: A Chemical and Molecular Review. Int. J. Nanotechnol. Nanomed. 2025, 10, 1-12.
  •  
  • 15. Priya, S.; Desai, V. M.; Singhvi, G. Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery. ACS Omega 2023, 8, 74-86.
  •  
  • 16. Siafaka, P. I.; Okur, N. Ü.; Karavas, E.; Bikiaris, D. N. Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses. Int. J. Mol. Sci. 2016, 17, 1440.
  •  
  • 17. Shin, J. Y.; Jin, B. S. Fabrication of Nanostructured Lipid Carriers Based on Ceramide–Phospholipid Mixtures. Appl. Chem. Eng. 2025, 36, 152-159.
  •  
  • 18. Kuhn, P. S.; Levin, Y.; Barbosa, M. C. Complex Formation between Polyelectrolytes and Ionic Surfactants. Chem. Phys. Lett. 1998, 298, 51-56.
  •  
  • 19. Berret, J. F. Sphere-to-Cylinder Transition in Hierarchical Electrostatic Complexes. Colloid Polym. Sci. 2009, 287, 801-810.
  •  
  • 20. Benderly, D.; Zolotarsky, Y. Beyond Thickening—Use of Alkyl Acrylate Crosspolymer in Personal Care Formulations. In Polymers for Personal Care and Cosmetics; ACS Symposium Series: Washington, D.C., 2013; Chapter 13, pp 205–218.
  •  
  • 21. Fan, Y.; Han, Y.; Wang, Y. Solubilization of Phosphatidylcholine Vesicles by Hydrophobically Modified Poly(acrylamide)-co-(acrylic acid): Effects of Acrylic Acid Fraction and Polymer Concentration. J. Phys. Chem. B 2007, 111, 10123-10129.
  •  
  • 22. Bhuyan, M. M.; Jeong, J. H. Preparation of Hydrogel by Crosslinking and Multi-Dimensional Applications. Gels 2025, 11, 896.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2026; 50(3): 477-485

    Published online May 25, 2026

  • 10.7317/pk.2026.50.3.477
  • Received on Feb 10, 2026
  • Revised on Mar 28, 2026
  • Accepted on Apr 4, 2026

Correspondence to

  • Byung Suk Jin

  • Division of Chemistry and Cosmetics, Dongduk Women’s University, Seoul 02748, Korea

  • E-mail: bsjin@dongduk.ac.kr