• Dexibuprofen Sucrose-Polymer Fibrous Matrices and Matrix Effects

  • Giwon Lee*,# , Won Kyung Kim*,# , Sunjae Park*, and Gilson Khang*, **, ***,†

  • *Department of PolymerNano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    **Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • 덱시부프로펜 자당-고분자 섬유 매트릭스와 매트릭스 효과

  • 이기원*,# · 김원경*,# · 박선재* · 강길선*, **, ***,†

  • *전북대학교 고분자나노공학과, **전북대학교 바이오나노융합공학과, ***전북대학교 고분자융합소재연구소

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Abioye, A. O.; Kola-Mustapha, A. Formulation Studies on Ibuprofen Sodium–Cationic Dextran Conjugate: Effect on Tableting and Dissolution Characteristics of Ibuprofen. Drug. Dev. Ind. Pharm. 2016, 42, 39-59.
  •  
  • 2. Kim, W. K.; Lee, G.; Park, S.; Khang, G. Formulation Study of HPMC-based Hot-melt Extruded Rebamipide Solid Dispersions for Solubility Enhancement and Sustained-release. Polym. Korea 2026, 50, 348-355.
  •  
  • 3. Lee, S. H.; Kim, J. Y.; Park, K. R.; Ha, D. H.; Kim, M. S. Enhancement of Solubility and Bioavailability of Dexibuprofen via Melt Spinning Process with Hydrophilic Polymers. Pharmaceutics. 2022, 14, 1152.
  •  
  • 4. Davies, N. M. Clinical Pharmacokinetics of Ibuprofen. The First 30 Years. Clin. Pharmacokinet. 1998, 34, 101-154.
  •  
  • 5. Pepin, X.; Blanchon, S.; Couarraze, G. Power Consumption Profiles in High–Shear Wet Granulation. II: Predicting the Overwetting Point from a Spreading Energy. J. Pharm. Sci. 2001, 90, 332-339.
  •  
  • 6. Abdel Rahim, S.; Al–Zoubi, N.; Gharaibeh, S.; Aljaberi, A. Kollidon® SR: Formulation Techniques and Drug Delivery Applications. Int. J. Pharm. 2025, 669, 125078.
  •  
  • 7. Obeidat, W. M.; Lahlouh, I. K.; Gharaibeh, S. F. Investigations on Compaction Behavior of Kollidon® SR Based Multi–component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium. AAPS PharmSciTech. 2023, 24, 225.
  •  
  • 8. Padayatty, S. J.; Levine, M. Vitamin C: The Known and the Unknown and Goldilocks. Oral Dis. 2016, 22, 463-493.
  •  
  • 9. Rainsford, K. D. Ibuprofen: Pharmacology, Efficacy and Safety. Inflammopharmacology. 2009, 17, 275-342.
  •  
  • 10. Roos, Y.; Karel, M. Amorphous State and Delayed Ice Formation in Sucrose Solutions. Int. J. Food Sci. Technol. 1991, 26, 553-566.
  •  
  • 11. Molina, A.; Vyas, P.; Khlystov, N.; Kumar, S.; Kothari, A.; Deriso, D.; Liu, Z.; Banavar, S.; Flaum, E.; Prakash, M. Low Cost Centrifugal Melt Spinning for Distributed Manufacturing of Non–Woven Media. PLoS One. 2022, 17, e0264933.
  •  
  • 12. Ye, H.; Zhou, L.; Zhou, J.; Xu, J.; Zhang, Z.; Wang, Y.; Zhao, M.; Li, W.; Yang, B.; Li, X. Flow Field Simulation and Experimental Study of Centrifugal Spinning. Fibers Polym. 2024, 25, 2751-2761.
  •  
  • 13. Qosim, N.; Majd, H.; Huo, S.; Edirisinghe, M.; Williams, G. R. Hydrophilic and Hydrophobic Drug Release from Core(Poly- vinylpyrrolidone)–Sheath (Ethyl Cellulose) Pressure–Spun Fibers. Int. J. Pharm. 2024, 654, 123972.
  •  
  • 14. Markl, D.; Zeitler, J. A. A Review of Disintegration Mechanisms and Measurement Techniques. Pharm. Res. 2017, 34, 890-917.
  •  
  • 15. Varma, M. V. S.; Kaushal, A. M.; Garg, A.; Garg, S. Factors Affecting Mechanism and Kinetics of Drug Release from Matrix-Based Oral Controlled Drug Delivery Systems. Am. J. Drug Deliv. 2004, 2, 43-57.
  •  
  • 16. Marano, S.; Barker, S. A.; Raimi-Abraham, B. T.; Missaghi, S.; Rajabi-Siahboomi, A.; Craig, D. Q. M. Development of Micro-Fibrous Solid Dispersions of Poorly Water-Soluble Drugs in Sucrose Using Temperature-Controlled Centrifugal Spinning. Eur. J. Pharm. Biopharm. 2016, 103, 84-94.
  •  
  • 17. Klang, V.; Valenta, C.; Matsko, N. B. Electron Microscopy of Pharmaceutical Systems. Micron. 2013, 44, 45-74.
  •  
  • 18. Smith, B. C. Fundamentals of Fourier Transform Infrared Spectroscopy, CRC Press: Boca Raton, 2011.
  •  
  • 19. Bhargava, R. Infrared Spectroscopic Imaging: The Next Generation. Appl. Spectrosc. 2012, 66, 1091-1120.
  •  
  • 20. Mallick, B.; Behera, R. C.; Patel, T. Analysis of Microstress in Neutron Irradiated Polyester Fibre by X-ray Diffraction Technique. Bull. Mater. Sci. 2005, 28, 593-598.
  •  
  • 21. Bunaciu, A. A.; Udriştioiu, E. G.; Aboul-Enein, H. Y. X-ray Diffraction: Instrumentation and Applications. Crit. Rev. Anal. Chem. 2015, 45, 289-299.
  •  
  • 22. Çavuşoglu Vatansever, H.; Ersoy Meriçboyu, A.; Karatepe, N. Multichannel Carbon Nanofiber Anode Materials Derived from Polyacrylonitrile/Cellulose Acetate Nanofibers with Improved Performance in Lithium-Ion Batteries. Nanotechnology 2026, 37, 115401.
  •  
  • 23. Ulrich, G. D.; Faez, R. Thermal, Mechanical and Physical Properties of Composite Films Developed from Seaweed Polysaccharides/Cellulose Nanofibers. J. Polym. Environ. 2022, 30, 3688-3700.
  •  
  • 24. Greer, B.; Chevallier, O.; Quinn, B.; Botana, L. M.; Elliott, C. T. Redefining Dilute and Shoot: The Evolution of the Technique and Its Application in the Analysis of Foods and Biological Matrices by Liquid Chromatography Mass Spectrometry. TrAC, Trends Anal. Chem. 2021, 141, 116284.
  •  
  • 25. Siepmann, F.; Eckart, K.; Maschke, A.; Kolter, K.; Siepmann, J. Modeling Drug Release from PVAc/PVP Matrix Tablets. J. Control. Release. 2010, 141, 216-222.
  •  
  • 26. Newa, M.; Bhandari, K. H.; Li, D. X.; Kim, J. O.; Yoo, D. S.; Kim, J. A.; Yoo, B.-K.; Woo, J. S.; Choi, H. G.; Yong, C. S. Preparation and Evaluation of Immediate Release Ibuprofen Solid Dispersions Using Polyethylene Glycol 4000. Biol. Pharm. Bull. 2008, 31, 939-945.
  •  
  • 27. Jeong, S. H.; Choi, D. H.; Kim, Y.; Kim, D. D. QbD Based Development and Evaluation of Topical Microemulsion-Based Hydrogel Against Superficial Fungal Infections. J. Pharm. Investig. 2019, 49, 87-103.
  •  
  • 28. Chiou, W. L.; Riegelman, S. Pharmaceutical Applications of Solid Dispersion Systems. J. Pharm. Sci. 1971, 60, 1281-1302.
  •  
  • 29. Verma, R. K.; Garg, S. Selection of Excipients for Extended Release Formulations of Glipizide through Drug–Excipient Compatibility Testing. J. Pharm. Biomed. Anal. 2005, 38, 633-644.
  •  
  • 30. Burnett, D. J.; Heng, J. Y. Y.; Thielmann, F.; Garcia, A. R.; Naderi, M.; Acharya, M. Measuring Surface Roughness of Pharmaceutical Powders Using Vapor Sorption Methods. AAPS PharmSciTech. 2011, 12, 56-61.
  •  
  • 31. Chadha, R.; Bhandari, S. Drug–Excipient Compatibility Screening–Role of Thermoanalytical and Spectroscopic Techniques. J. Pharm. Biomed. Anal. 2014, 87, 82-97.
  •  
  • 32. Castillo-Henríquez, L.; Vargas-Zúñiga, R.; Pacheco-Molina, J.; Vega-Baudrit, J. Electrospun Nanofibers: A Nanotechnological Approach for Drug Delivery and Dissolution Optimization in Poorly Water-Soluble Drugs. ADMET & DMPK. 2020, 8, 325-353.
  •  
  • 33. Thakral, N. K.; Zanon, R. L.; Kelly, R. C.; Thakral, S. Applications of Powder X–Ray Diffraction in Small Molecule Pharmaceuticals: Achievements and Aspirations. J. Pharm. Sci. 2018, 107, 2969-2982.
  •  
  • 34. Banks, D. D.; Hambly, D. M.; Scavezze, J. L.; Siska, C. C.; Stackhouse, N. L.; Gadgil, H. S. The Effect of Sucrose Hydrolysis on the Stability of Protein Therapeutics During Accelerated Formulation Studies. J. Pharm. Sci. 2009, 98, 4501-4510.
  •  
  • 35. Tiwari, M.; Mhatre, S.; Vyas, T.; Bapna, A.; Raghavan, G. A Validated HPLC-RID Method for Quantification and Optimization of Total Sugars: Fructose, Glucose, Sucrose, and Lactose in Eggless Mayonnaise. Separations. 2023, 10, 199.
  •  
  • 36. Kinoshita, R.; Ohta, T.; Shiraki, K.; Higashi, K.; Moribe, K. Effects of Wet-granulation Process Parameters on the Dissolution and Physical Stability of a Solid Dispersion. Int. J. Pharm. 2017, 524, 304-311.
  •  
  • 37. Gehrmann, S.; Bunjes, H. Preparation of Nanoemulsions by Premix Membrane Emulsification: Parameters Affecting Droplet Size and Polydispersity. J. Pharm. Sci. 2017, 106, 2068-2076.
  •  
  • 38. Aitipamula, S.; Banerjee, R.; Bansal, A. K.; Biradha, K.; Cheney, M. L.; Choudhury, A. R.; Desiraju, G. R.; Dikundwar, A. G.; Dubey, R.; Duggirala, N. et al. Polymorphs, Salts, and Cocrystals: What’s in a Name? Cryst. Growth Des. 2012, 12, 2147-2152.
  •  
  • 39. Hancock, B. C.; Zografi, G. Characteristics and Significance of the Amorphous State in Pharmaceutical Systems. J. Pharm. Sci. 1997, 86, 1-12.
  •  
  • 40. Roe, K. D.; Labuza, T. P. Glass Transition and Crystallization of Amorphous Trehalose–Sucrose Mixtures. Int. J. Food Prop. 2005, 8, 559-574.
  •  
  • 41. Hemilä, H. Vitamin C and Infections. Nutrients. 2017, 9, 33.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2025 Impact Factor : 1.0
  • Indexed in SCIE

This Article

  • 2026; 50(4): 588-599

    Published online Jul 25, 2026

  • 10.7317/pk.2026.50.4.588
  • Received on Mar 31, 2026
  • Revised on May 20, 2026
  • Accepted on May 22, 2026

Correspondence to

  • Gilson Khang

  • *Department of PolymerNano Science & Technology, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    **Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea
    ***Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Korea

  • E-mail: gskhang@jbnu.ac.kr